<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e8417-2a15-72d0-a88a-88087aa76e30,g:af5ad5c6-69a5-470c-94c7-06716aa3560e-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.contexttherapeutics.com/role/CondensedConsolidatedStatementsofChangesinStockholdersEquityUnaudited" xlink:type="simple" xlink:href="cntx-20260630.xsd#CondensedConsolidatedStatementsofChangesinStockholdersEquityUnaudited"/>
  <link:definitionLink xlink:role="http://www.contexttherapeutics.com/role/CondensedConsolidatedStatementsofChangesinStockholdersEquityUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019e8417-2a15-767d-88d5-261680156248" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019e8417-2a15-798c-ba3b-47d009692438" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019e8417-2a15-767d-88d5-261680156248" xlink:to="loc_us-gaap_StatementTable_019e8417-2a15-798c-ba3b-47d009692438" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019e8417-2a15-7a60-abd6-bf8983208564" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019e8417-2a15-798c-ba3b-47d009692438" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019e8417-2a15-7a60-abd6-bf8983208564" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019e8417-2a15-7a60-abd6-bf8983208564_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019e8417-2a15-7a60-abd6-bf8983208564" xlink:to="loc_us-gaap_EquityComponentDomain_019e8417-2a15-7a60-abd6-bf8983208564_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019e8417-2a15-75aa-b84a-9a2dcd2f0233" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019e8417-2a15-7a60-abd6-bf8983208564" xlink:to="loc_us-gaap_EquityComponentDomain_019e8417-2a15-75aa-b84a-9a2dcd2f0233" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019e8417-2a15-7835-b7ef-a7297fd849e2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019e8417-2a15-75aa-b84a-9a2dcd2f0233" xlink:to="loc_us-gaap_CommonStockMember_019e8417-2a15-7835-b7ef-a7297fd849e2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_019e8417-2a15-7760-b1cc-0e9d49949237" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019e8417-2a15-75aa-b84a-9a2dcd2f0233" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_019e8417-2a15-7760-b1cc-0e9d49949237" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_019e8417-2a15-7636-8aeb-589164d81d1f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019e8417-2a15-75aa-b84a-9a2dcd2f0233" xlink:to="loc_us-gaap_RetainedEarningsMember_019e8417-2a15-7636-8aeb-589164d81d1f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e8417-2a15-7b64-abb7-d9995f1e326c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e8417-2a15-767d-88d5-261680156248" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e8417-2a15-7b64-abb7-d9995f1e326c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019e8417-2a15-74a9-b089-d748ac5620b3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e8417-2a15-7b64-abb7-d9995f1e326c" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_019e8417-2a15-74a9-b089-d748ac5620b3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e8417-2a15-7595-ba3d-93ba3f3c1959" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e8417-2a15-7b64-abb7-d9995f1e326c" xlink:to="loc_us-gaap_StockholdersEquity_019e8417-2a15-7595-ba3d-93ba3f3c1959" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019e8417-2a15-7063-a1a3-32bb23d3185d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e8417-2a15-7b64-abb7-d9995f1e326c" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019e8417-2a15-7063-a1a3-32bb23d3185d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e8417-2a15-7580-9e23-dd59055cca80" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019e8417-2a15-7b64-abb7-d9995f1e326c" xlink:to="loc_us-gaap_NetIncomeLoss_019e8417-2a15-7580-9e23-dd59055cca80" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019e8417-2a15-75d2-a992-93526d1caa3c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e8417-2a15-7363-b432-d9fdea79d04b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contexttherapeutics.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesSummaryofSignificantExpenseCategoriesReviewedByTheCODMDetails" xlink:type="simple" xlink:href="cntx-20260630.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesSummaryofSignificantExpenseCategoriesReviewedByTheCODMDetails"/>
  <link:definitionLink xlink:role="http://www.contexttherapeutics.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesSummaryofSignificantExpenseCategoriesReviewedByTheCODMDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemLineItems_019e8417-2a15-7eb5-8490-f4f21e19fe14" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentReportingOtherSignificantReconcilingItemLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReconciliationOfOtherSignificantReconcilingItemsFromSegmentsToConsolidatedTable_019e8417-2a15-74c4-b2fc-d81d9352b069" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ReconciliationOfOtherSignificantReconcilingItemsFromSegmentsToConsolidatedTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemLineItems_019e8417-2a15-7eb5-8490-f4f21e19fe14" xlink:to="loc_us-gaap_ReconciliationOfOtherSignificantReconcilingItemsFromSegmentsToConsolidatedTable_019e8417-2a15-74c4-b2fc-d81d9352b069" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019e8417-2a15-7a5b-a1c0-cd35945176c4" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ReconciliationOfOtherSignificantReconcilingItemsFromSegmentsToConsolidatedTable_019e8417-2a15-74c4-b2fc-d81d9352b069" xlink:to="loc_srt_ProductOrServiceAxis_019e8417-2a15-7a5b-a1c0-cd35945176c4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e8417-2a15-7a5b-a1c0-cd35945176c4_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019e8417-2a15-7a5b-a1c0-cd35945176c4" xlink:to="loc_srt_ProductsAndServicesDomain_019e8417-2a15-7a5b-a1c0-cd35945176c4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019e8417-2a15-7e13-b79d-5a6a9783073f" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019e8417-2a15-7a5b-a1c0-cd35945176c4" xlink:to="loc_srt_ProductsAndServicesDomain_019e8417-2a15-7e13-b79d-5a6a9783073f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_CTIM76Member_019e8417-2a15-7188-a94e-c103dc42bd58" xlink:href="cntx-20260630.xsd#cntx_CTIM76Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e8417-2a15-7e13-b79d-5a6a9783073f" xlink:to="loc_cntx_CTIM76Member_019e8417-2a15-7188-a94e-c103dc42bd58" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_CT95Member_019e8417-2a15-7ee5-b6b9-a7075a26cced" xlink:href="cntx-20260630.xsd#cntx_CT95Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e8417-2a15-7e13-b79d-5a6a9783073f" xlink:to="loc_cntx_CT95Member_019e8417-2a15-7ee5-b6b9-a7075a26cced" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_CT202Member_019e8417-2a15-7775-9277-af1cff48505e" xlink:href="cntx-20260630.xsd#cntx_CT202Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019e8417-2a15-7e13-b79d-5a6a9783073f" xlink:to="loc_cntx_CT202Member_019e8417-2a15-7775-9277-af1cff48505e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019e8417-2a15-7eb6-8544-e0c1128dc63e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ReconciliationOfOtherSignificantReconcilingItemsFromSegmentsToConsolidatedTable_019e8417-2a15-74c4-b2fc-d81d9352b069" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019e8417-2a15-7eb6-8544-e0c1128dc63e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019e8417-2a15-7eb6-8544-e0c1128dc63e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019e8417-2a15-7eb6-8544-e0c1128dc63e" xlink:to="loc_us-gaap_SegmentDomain_019e8417-2a15-7eb6-8544-e0c1128dc63e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019e8417-2a15-7edb-8ff5-af4bb296717a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019e8417-2a15-7eb6-8544-e0c1128dc63e" xlink:to="loc_us-gaap_SegmentDomain_019e8417-2a15-7edb-8ff5-af4bb296717a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_ReportableSegmentMember_019e8417-2a15-74c6-bf0c-fd79e9e9ef14" xlink:href="cntx-20260630.xsd#cntx_ReportableSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019e8417-2a15-7edb-8ff5-af4bb296717a" xlink:to="loc_cntx_ReportableSegmentMember_019e8417-2a15-74c6-bf0c-fd79e9e9ef14" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019e8417-2a15-780c-9e05-6fc97f8e1bd4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemLineItems_019e8417-2a15-7eb5-8490-f4f21e19fe14" xlink:to="loc_us-gaap_OperatingExpenses_019e8417-2a15-780c-9e05-6fc97f8e1bd4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_019e8417-2a15-774e-a156-827596a11d20" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemLineItems_019e8417-2a15-7eb5-8490-f4f21e19fe14" xlink:to="loc_us-gaap_LaborAndRelatedExpense_019e8417-2a15-774e-a156-827596a11d20" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfessionalFees_019e8417-2a15-74ee-914b-fdb6682f33ca" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProfessionalFees"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemLineItems_019e8417-2a15-7eb5-8490-f4f21e19fe14" xlink:to="loc_us-gaap_ProfessionalFees_019e8417-2a15-74ee-914b-fdb6682f33ca" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019e8417-2a15-72a9-a54a-1ea1ac8763a1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemLineItems_019e8417-2a15-7eb5-8490-f4f21e19fe14" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019e8417-2a15-72a9-a54a-1ea1ac8763a1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingOtherItemAmount_019e8417-2a15-7529-87d9-80fff98066ae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentReportingOtherItemAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemLineItems_019e8417-2a15-7eb5-8490-f4f21e19fe14" xlink:to="loc_us-gaap_SegmentReportingOtherItemAmount_019e8417-2a15-7529-87d9-80fff98066ae" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e8417-2a15-7400-886e-f85312dc6f85" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemLineItems_019e8417-2a15-7eb5-8490-f4f21e19fe14" xlink:to="loc_us-gaap_OperatingIncomeLoss_019e8417-2a15-7400-886e-f85312dc6f85" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_019e8417-2a15-7f8d-b6c3-b541e163d35e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemLineItems_019e8417-2a15-7eb5-8490-f4f21e19fe14" xlink:to="loc_us-gaap_InvestmentIncomeInterest_019e8417-2a15-7f8d-b6c3-b541e163d35e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019e8417-2a15-7d07-91e5-4479ed19f98e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemLineItems_019e8417-2a15-7eb5-8490-f4f21e19fe14" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019e8417-2a15-7d07-91e5-4479ed19f98e" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e8417-2a15-7d70-b803-2bfee44641fc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingOtherSignificantReconcilingItemLineItems_019e8417-2a15-7eb5-8490-f4f21e19fe14" xlink:to="loc_us-gaap_NetIncomeLoss_019e8417-2a15-7d70-b803-2bfee44641fc" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contexttherapeutics.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesScheduleofAntidilutiveSecuritiesExcludedfromComputationofEarningsPerShareDetails" xlink:type="simple" xlink:href="cntx-20260630.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesScheduleofAntidilutiveSecuritiesExcludedfromComputationofEarningsPerShareDetails"/>
  <link:definitionLink xlink:role="http://www.contexttherapeutics.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesScheduleofAntidilutiveSecuritiesExcludedfromComputationofEarningsPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019e8417-2a15-744d-ae76-38c4a795b97a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019e8417-2a15-7c2c-82c6-d2815ba9e993" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019e8417-2a15-744d-ae76-38c4a795b97a" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019e8417-2a15-7c2c-82c6-d2815ba9e993" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019e8417-2a15-742a-b7c7-f81765b0eb3a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019e8417-2a15-7c2c-82c6-d2815ba9e993" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019e8417-2a15-742a-b7c7-f81765b0eb3a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e8417-2a15-742a-b7c7-f81765b0eb3a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019e8417-2a15-742a-b7c7-f81765b0eb3a" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e8417-2a15-742a-b7c7-f81765b0eb3a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e8417-2a15-7ad2-a0cc-d1eb1f77df01" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019e8417-2a15-742a-b7c7-f81765b0eb3a" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e8417-2a15-7ad2-a0cc-d1eb1f77df01" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019e8417-2a15-7784-a308-6473fa39a509" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e8417-2a15-7ad2-a0cc-d1eb1f77df01" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019e8417-2a15-7784-a308-6473fa39a509" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_019e8417-2a15-70a9-bc4a-6201b896d01a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019e8417-2a15-7ad2-a0cc-d1eb1f77df01" xlink:to="loc_us-gaap_WarrantMember_019e8417-2a15-70a9-bc4a-6201b896d01a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019e8417-2a15-786a-bbbc-e14cbeb4c27b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019e8417-2a15-744d-ae76-38c4a795b97a" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019e8417-2a15-786a-bbbc-e14cbeb4c27b" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contexttherapeutics.com/role/FairValueMeasurementsScheduleofassetsandliabilitiesmeasuredatfairvalueonarecurringbasisDetails" xlink:type="simple" xlink:href="cntx-20260630.xsd#FairValueMeasurementsScheduleofassetsandliabilitiesmeasuredatfairvalueonarecurringbasisDetails"/>
  <link:definitionLink xlink:role="http://www.contexttherapeutics.com/role/FairValueMeasurementsScheduleofassetsandliabilitiesmeasuredatfairvalueonarecurringbasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e8417-2a15-7ec7-9174-3e7efe77aed7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019e8417-2a15-73ea-b610-27ca712ac522" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e8417-2a15-7ec7-9174-3e7efe77aed7" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019e8417-2a15-73ea-b610-27ca712ac522" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_019e8417-2a15-7d44-9dd0-49cc9b9f5332" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019e8417-2a15-73ea-b610-27ca712ac522" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_019e8417-2a15-7d44-9dd0-49cc9b9f5332" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019e8417-2a15-7d44-9dd0-49cc9b9f5332_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019e8417-2a15-7d44-9dd0-49cc9b9f5332" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019e8417-2a15-7d44-9dd0-49cc9b9f5332_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019e8417-2a15-754e-b7d2-8920c47071c5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019e8417-2a15-7d44-9dd0-49cc9b9f5332" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019e8417-2a15-754e-b7d2-8920c47071c5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_019e8417-2a15-7694-95aa-cdf6a2c0c87e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019e8417-2a15-754e-b7d2-8920c47071c5" xlink:to="loc_us-gaap_MoneyMarketFundsMember_019e8417-2a15-7694-95aa-cdf6a2c0c87e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019e8417-2a15-7170-acf5-0d83efe695d8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019e8417-2a15-73ea-b610-27ca712ac522" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019e8417-2a15-7170-acf5-0d83efe695d8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e8417-2a15-7170-acf5-0d83efe695d8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019e8417-2a15-7170-acf5-0d83efe695d8" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e8417-2a15-7170-acf5-0d83efe695d8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e8417-2a15-754c-b274-4621c38e245c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019e8417-2a15-7170-acf5-0d83efe695d8" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e8417-2a15-754c-b274-4621c38e245c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_019e8417-2a15-7f30-9331-c66e19838fe7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e8417-2a15-754c-b274-4621c38e245c" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_019e8417-2a15-7f30-9331-c66e19838fe7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019e8417-2a15-730f-a144-8cad2556a11f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e8417-2a15-754c-b274-4621c38e245c" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019e8417-2a15-730f-a144-8cad2556a11f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019e8417-2a15-7af8-ab07-655543aec175" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019e8417-2a15-754c-b274-4621c38e245c" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019e8417-2a15-7af8-ab07-655543aec175" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_019e8417-2a15-7444-93b9-daa016dca349" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e8417-2a15-7ec7-9174-3e7efe77aed7" xlink:to="loc_us-gaap_AssetsFairValueDisclosureAbstract_019e8417-2a15-7444-93b9-daa016dca349" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019e8417-2a15-7524-8f01-beec89d25146" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_019e8417-2a15-7444-93b9-daa016dca349" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019e8417-2a15-7524-8f01-beec89d25146" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contexttherapeutics.com/role/StockholdersEquityNarrativeDetails" xlink:type="simple" xlink:href="cntx-20260630.xsd#StockholdersEquityNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.contexttherapeutics.com/role/StockholdersEquityNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8417-2ade-7129-8f62-77ef84246609" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_019e8417-2a15-7a4e-80c7-74188a8987a6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8417-2ade-7129-8f62-77ef84246609" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_019e8417-2a15-7a4e-80c7-74188a8987a6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_019e8417-2a15-78bf-a8a7-090438c4df6f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_019e8417-2a15-7a4e-80c7-74188a8987a6" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_019e8417-2a15-78bf-a8a7-090438c4df6f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019e8417-2a15-78bf-a8a7-090438c4df6f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019e8417-2a15-78bf-a8a7-090438c4df6f" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019e8417-2a15-78bf-a8a7-090438c4df6f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019e8417-2a15-723c-b5dd-74372b3b99ef" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019e8417-2a15-78bf-a8a7-090438c4df6f" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019e8417-2a15-723c-b5dd-74372b3b99ef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrivatePlacementMember_019e8417-2a15-70a0-83e1-a5ec986778a1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrivatePlacementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019e8417-2a15-723c-b5dd-74372b3b99ef" xlink:to="loc_us-gaap_PrivatePlacementMember_019e8417-2a15-70a0-83e1-a5ec986778a1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_AtTheMarketFacilityMember_019e8417-2a15-7968-b999-9f11fa834e5a" xlink:href="cntx-20260630.xsd#cntx_AtTheMarketFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019e8417-2a15-723c-b5dd-74372b3b99ef" xlink:to="loc_cntx_AtTheMarketFacilityMember_019e8417-2a15-7968-b999-9f11fa834e5a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_019e8417-2ade-70f5-a2c0-c5b8d0ea82f4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_019e8417-2a15-7a4e-80c7-74188a8987a6" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_019e8417-2ade-70f5-a2c0-c5b8d0ea82f4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8417-2ade-70f5-a2c0-c5b8d0ea82f4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019e8417-2ade-70f5-a2c0-c5b8d0ea82f4" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8417-2ade-70f5-a2c0-c5b8d0ea82f4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8417-2ade-7eef-9e8e-e930c992a380" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019e8417-2ade-70f5-a2c0-c5b8d0ea82f4" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8417-2ade-7eef-9e8e-e930c992a380" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_IssuedForProfessionalConsultingServicesMember_019e8417-2ade-78ee-8e5d-73b94ae0e3b0" xlink:href="cntx-20260630.xsd#cntx_IssuedForProfessionalConsultingServicesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8417-2ade-7eef-9e8e-e930c992a380" xlink:to="loc_cntx_IssuedForProfessionalConsultingServicesMember_019e8417-2ade-78ee-8e5d-73b94ae0e3b0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_IssuedInConnectionWithPrivatePlacementMember_019e8417-2ade-73c1-8b86-b90bc545e727" xlink:href="cntx-20260630.xsd#cntx_IssuedInConnectionWithPrivatePlacementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8417-2ade-7eef-9e8e-e930c992a380" xlink:to="loc_cntx_IssuedInConnectionWithPrivatePlacementMember_019e8417-2ade-73c1-8b86-b90bc545e727" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_019e8417-2ade-7291-bc98-1ef48cfef157" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8417-2ade-7129-8f62-77ef84246609" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_019e8417-2ade-7291-bc98-1ef48cfef157" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019e8417-2ade-7e28-ad33-9f2e4d9a14e9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8417-2ade-7129-8f62-77ef84246609" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019e8417-2ade-7e28-ad33-9f2e4d9a14e9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_019e8417-2ade-718b-b2df-f047200e65e3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8417-2ade-7129-8f62-77ef84246609" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_019e8417-2ade-718b-b2df-f047200e65e3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_019e8417-2ade-7de7-ac33-6a8e76e246f4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8417-2ade-7129-8f62-77ef84246609" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_019e8417-2ade-7de7-ac33-6a8e76e246f4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_ClassOfWarrantOrRightPurchasePrice_019e8417-2ade-7eb3-9e85-89d7f2f1fa0f" xlink:href="cntx-20260630.xsd#cntx_ClassOfWarrantOrRightPurchasePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8417-2ade-7129-8f62-77ef84246609" xlink:to="loc_cntx_ClassOfWarrantOrRightPurchasePrice_019e8417-2ade-7eb3-9e85-89d7f2f1fa0f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_019e8417-2ade-76e7-8a79-934a86917c1d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8417-2ade-7129-8f62-77ef84246609" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_019e8417-2ade-76e7-8a79-934a86917c1d" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_ClassOfWarrantOrRightNumberOfWarrantsExercised_019e8417-2ade-7b81-8c39-e4f5f85fc5da" xlink:href="cntx-20260630.xsd#cntx_ClassOfWarrantOrRightNumberOfWarrantsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8417-2ade-7129-8f62-77ef84246609" xlink:to="loc_cntx_ClassOfWarrantOrRightNumberOfWarrantsExercised_019e8417-2ade-7b81-8c39-e4f5f85fc5da" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_StockAndWarrantsIssuedDuringPeriodSharesWarrantsExercised_019e8417-2ade-7384-8f34-eff33773e2e7" xlink:href="cntx-20260630.xsd#cntx_StockAndWarrantsIssuedDuringPeriodSharesWarrantsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8417-2ade-7129-8f62-77ef84246609" xlink:to="loc_cntx_StockAndWarrantsIssuedDuringPeriodSharesWarrantsExercised_019e8417-2ade-7384-8f34-eff33773e2e7" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_019e8417-2ade-7653-9118-9adc3805725f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8417-2ade-7129-8f62-77ef84246609" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_019e8417-2ade-7653-9118-9adc3805725f" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_SaleOfStockAggregateOfferingAmount_019e8417-2ade-7385-a88d-a87fe46ee3d0" xlink:href="cntx-20260630.xsd#cntx_SaleOfStockAggregateOfferingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8417-2ade-7129-8f62-77ef84246609" xlink:to="loc_cntx_SaleOfStockAggregateOfferingAmount_019e8417-2ade-7385-a88d-a87fe46ee3d0" xlink:type="arc" order="9"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contexttherapeutics.com/role/StockholdersEquityScheduleofWarrantsOutstandingDetails" xlink:type="simple" xlink:href="cntx-20260630.xsd#StockholdersEquityScheduleofWarrantsOutstandingDetails"/>
  <link:definitionLink xlink:role="http://www.contexttherapeutics.com/role/StockholdersEquityScheduleofWarrantsOutstandingDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8417-2ade-7969-b71c-08fa0dd74867" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_019e8417-2ade-7fe6-a2fa-b5ebde7588e9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8417-2ade-7969-b71c-08fa0dd74867" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_019e8417-2ade-7fe6-a2fa-b5ebde7588e9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_019e8417-2ade-75e6-9bb1-e5a66cf82e8b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_019e8417-2ade-7fe6-a2fa-b5ebde7588e9" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_019e8417-2ade-75e6-9bb1-e5a66cf82e8b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8417-2ade-75e6-9bb1-e5a66cf82e8b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019e8417-2ade-75e6-9bb1-e5a66cf82e8b" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8417-2ade-75e6-9bb1-e5a66cf82e8b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8417-2ade-706a-a978-23d652c05a03" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019e8417-2ade-75e6-9bb1-e5a66cf82e8b" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8417-2ade-706a-a978-23d652c05a03" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_IssuedToPlacementAgentsMember_019e8417-2ade-7e59-98c6-07f2b39cefd3" xlink:href="cntx-20260630.xsd#cntx_IssuedToPlacementAgentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8417-2ade-706a-a978-23d652c05a03" xlink:to="loc_cntx_IssuedToPlacementAgentsMember_019e8417-2ade-7e59-98c6-07f2b39cefd3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_December2021PrivatePlacementAgentWarrantsMember_019e8417-2ade-76cb-9acf-9fe7501541a3" xlink:href="cntx-20260630.xsd#cntx_December2021PrivatePlacementAgentWarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8417-2ade-706a-a978-23d652c05a03" xlink:to="loc_cntx_December2021PrivatePlacementAgentWarrantsMember_019e8417-2ade-76cb-9acf-9fe7501541a3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_IssuedForProfessionalConsultingServicesMember_019e8417-2ade-7bea-8402-5d439e089481" xlink:href="cntx-20260630.xsd#cntx_IssuedForProfessionalConsultingServicesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8417-2ade-706a-a978-23d652c05a03" xlink:to="loc_cntx_IssuedForProfessionalConsultingServicesMember_019e8417-2ade-7bea-8402-5d439e089481" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_IssuedInConnectionWithPrivatePlacementMember_019e8417-2ade-79b0-bccb-2a88c49ceef1" xlink:href="cntx-20260630.xsd#cntx_IssuedInConnectionWithPrivatePlacementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019e8417-2ade-706a-a978-23d652c05a03" xlink:to="loc_cntx_IssuedInConnectionWithPrivatePlacementMember_019e8417-2ade-79b0-bccb-2a88c49ceef1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_019e8417-2ade-7478-a646-57816fbd19a5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8417-2ade-7969-b71c-08fa0dd74867" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_019e8417-2ade-7478-a646-57816fbd19a5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_019e8417-2ade-70c6-bfaa-b42d93a52b04" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019e8417-2ade-7969-b71c-08fa0dd74867" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_019e8417-2ade-70c6-bfaa-b42d93a52b04" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contexttherapeutics.com/role/ShareBasedCompensationAdditionalInformationDetails" xlink:type="simple" xlink:href="cntx-20260630.xsd#ShareBasedCompensationAdditionalInformationDetails"/>
  <link:definitionLink xlink:role="http://www.contexttherapeutics.com/role/ShareBasedCompensationAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-73b1-b446-093a4b45f5ca" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e8417-2ade-786e-8c5a-7bbc04923c59" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-73b1-b446-093a4b45f5ca" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e8417-2ade-786e-8c5a-7bbc04923c59" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019e8417-2ade-7a2b-aac7-e07fe612825a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e8417-2ade-786e-8c5a-7bbc04923c59" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019e8417-2ade-7a2b-aac7-e07fe612825a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019e8417-2ade-7a2b-aac7-e07fe612825a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019e8417-2ade-7a2b-aac7-e07fe612825a" xlink:to="loc_us-gaap_ClassOfStockDomain_019e8417-2ade-7a2b-aac7-e07fe612825a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019e8417-2ade-7e54-81b5-df85a957b56f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019e8417-2ade-7a2b-aac7-e07fe612825a" xlink:to="loc_us-gaap_ClassOfStockDomain_019e8417-2ade-7e54-81b5-df85a957b56f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019e8417-2ade-7e1b-b186-5f509e5ec156" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019e8417-2ade-7e54-81b5-df85a957b56f" xlink:to="loc_us-gaap_CommonClassAMember_019e8417-2ade-7e1b-b186-5f509e5ec156" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019e8417-2ade-7972-a6a8-56367ac38936" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019e8417-2ade-7e54-81b5-df85a957b56f" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019e8417-2ade-7972-a6a8-56367ac38936" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019e8417-2ade-73ee-b9fd-124a6efabb4b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e8417-2ade-786e-8c5a-7bbc04923c59" xlink:to="loc_us-gaap_AwardTypeAxis_019e8417-2ade-73ee-b9fd-124a6efabb4b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e8417-2ade-73ee-b9fd-124a6efabb4b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019e8417-2ade-73ee-b9fd-124a6efabb4b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e8417-2ade-73ee-b9fd-124a6efabb4b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e8417-2ade-7cae-8295-531e164c5051" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019e8417-2ade-73ee-b9fd-124a6efabb4b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e8417-2ade-7cae-8295-531e164c5051" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019e8417-2ade-7256-b527-eeb379ea9e59" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e8417-2ade-7cae-8295-531e164c5051" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019e8417-2ade-7256-b527-eeb379ea9e59" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019e8417-2ade-79a9-b121-1b240424405c" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e8417-2ade-786e-8c5a-7bbc04923c59" xlink:to="loc_srt_RangeAxis_019e8417-2ade-79a9-b121-1b240424405c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e8417-2ade-79a9-b121-1b240424405c_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019e8417-2ade-79a9-b121-1b240424405c" xlink:to="loc_srt_RangeMember_019e8417-2ade-79a9-b121-1b240424405c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e8417-2ade-7d4e-be50-8b33b0161331" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019e8417-2ade-79a9-b121-1b240424405c" xlink:to="loc_srt_RangeMember_019e8417-2ade-7d4e-be50-8b33b0161331" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019e8417-2ade-7f3a-b834-40df3cbeed9e" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e8417-2ade-7d4e-be50-8b33b0161331" xlink:to="loc_srt_MinimumMember_019e8417-2ade-7f3a-b834-40df3cbeed9e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019e8417-2ade-7b7c-b26f-4852f77e1f18" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e8417-2ade-7d4e-be50-8b33b0161331" xlink:to="loc_srt_MaximumMember_019e8417-2ade-7b7c-b26f-4852f77e1f18" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_019e8417-2ade-79a8-a366-e36877d611bd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-73b1-b446-093a4b45f5ca" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_019e8417-2ade-79a8-a366-e36877d611bd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalSharesAuthorizedAsAPercentageOfOutstandingStock_019e8417-2ade-7371-8b26-2d76e941b959" xlink:href="cntx-20260630.xsd#cntx_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalSharesAuthorizedAsAPercentageOfOutstandingStock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-73b1-b446-093a4b45f5ca" xlink:to="loc_cntx_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalSharesAuthorizedAsAPercentageOfOutstandingStock_019e8417-2ade-7371-8b26-2d76e941b959" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_019e8417-2ade-72ca-8dc8-d30ed56f76c3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-73b1-b446-093a4b45f5ca" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_019e8417-2ade-72ca-8dc8-d30ed56f76c3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_019e8417-2ade-7e62-b2ee-24a270e2f728" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-73b1-b446-093a4b45f5ca" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_019e8417-2ade-7e62-b2ee-24a270e2f728" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_019e8417-2ade-7a6f-9a6f-998941b9f4f7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-73b1-b446-093a4b45f5ca" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_019e8417-2ade-7a6f-9a6f-998941b9f4f7" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_019e8417-2ade-76cf-be98-d5ddb8aa0988" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-73b1-b446-093a4b45f5ca" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_019e8417-2ade-76cf-be98-d5ddb8aa0988" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019e8417-2ade-7494-9919-bcf1735f2c6e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-73b1-b446-093a4b45f5ca" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019e8417-2ade-7494-9919-bcf1735f2c6e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_019e8417-2ade-7524-95cf-513a06a92e1d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-73b1-b446-093a4b45f5ca" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_019e8417-2ade-7524-95cf-513a06a92e1d" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_019e8417-2ade-7891-803f-efe33c466d1f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-73b1-b446-093a4b45f5ca" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_019e8417-2ade-7891-803f-efe33c466d1f" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contexttherapeutics.com/role/ShareBasedCompensationScheduleofSharebasedCompensationExpenseDetails" xlink:type="simple" xlink:href="cntx-20260630.xsd#ShareBasedCompensationScheduleofSharebasedCompensationExpenseDetails"/>
  <link:definitionLink xlink:role="http://www.contexttherapeutics.com/role/ShareBasedCompensationScheduleofSharebasedCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019e8417-2ade-77db-9218-7180e2c98449" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019e8417-2ade-7dd5-a330-285bc3d3135b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019e8417-2ade-77db-9218-7180e2c98449" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019e8417-2ade-7dd5-a330-285bc3d3135b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_019e8417-2ade-728d-bb7a-c6b5c41e14d5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019e8417-2ade-7dd5-a330-285bc3d3135b" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_019e8417-2ade-728d-bb7a-c6b5c41e14d5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019e8417-2ade-728d-bb7a-c6b5c41e14d5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019e8417-2ade-728d-bb7a-c6b5c41e14d5" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019e8417-2ade-728d-bb7a-c6b5c41e14d5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019e8417-2ade-7ecc-b516-c4b5218fadbc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019e8417-2ade-728d-bb7a-c6b5c41e14d5" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019e8417-2ade-7ecc-b516-c4b5218fadbc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_019e8417-2ade-767b-a275-ac994f198600" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019e8417-2ade-7ecc-b516-c4b5218fadbc" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_019e8417-2ade-767b-a275-ac994f198600" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_019e8417-2ade-7db2-974f-e3439d9366ba" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019e8417-2ade-7ecc-b516-c4b5218fadbc" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_019e8417-2ade-7db2-974f-e3439d9366ba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019e8417-2ade-7a45-a156-c8762154ae0f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019e8417-2ade-77db-9218-7180e2c98449" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019e8417-2ade-7a45-a156-c8762154ae0f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contexttherapeutics.com/role/ShareBasedCompensationScheduleofAssumptionsUsedtoDetermineFairValueofShareBasedAwardsDetails" xlink:type="simple" xlink:href="cntx-20260630.xsd#ShareBasedCompensationScheduleofAssumptionsUsedtoDetermineFairValueofShareBasedAwardsDetails"/>
  <link:definitionLink xlink:role="http://www.contexttherapeutics.com/role/ShareBasedCompensationScheduleofAssumptionsUsedtoDetermineFairValueofShareBasedAwardsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-74ea-a715-7ec18fded5ef" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e8417-2ade-71ab-9e7a-b26fb57b6939" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-74ea-a715-7ec18fded5ef" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e8417-2ade-71ab-9e7a-b26fb57b6939" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019e8417-2ade-7b72-9a53-65a6d93078b1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019e8417-2ade-71ab-9e7a-b26fb57b6939" xlink:to="loc_us-gaap_AwardTypeAxis_019e8417-2ade-7b72-9a53-65a6d93078b1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e8417-2ade-7b72-9a53-65a6d93078b1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019e8417-2ade-7b72-9a53-65a6d93078b1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e8417-2ade-7b72-9a53-65a6d93078b1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e8417-2ade-7e6c-93cc-bb81d77ec6eb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019e8417-2ade-7b72-9a53-65a6d93078b1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e8417-2ade-7e6c-93cc-bb81d77ec6eb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019e8417-2ade-7ffc-8e1a-f5ef2c91b245" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019e8417-2ade-7e6c-93cc-bb81d77ec6eb" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019e8417-2ade-7ffc-8e1a-f5ef2c91b245" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_019e8417-2ade-74a3-aa7b-e86af610d815" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-74ea-a715-7ec18fded5ef" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_019e8417-2ade-74a3-aa7b-e86af610d815" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_019e8417-2ade-72c1-832a-211288be46bb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-74ea-a715-7ec18fded5ef" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_019e8417-2ade-72c1-832a-211288be46bb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_019e8417-2ade-70a5-aee3-aa3d9d7861de" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-74ea-a715-7ec18fded5ef" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_019e8417-2ade-70a5-aee3-aa3d9d7861de" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_019e8417-2ade-72e5-b8cc-76e690cf8a19" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019e8417-2ade-74ea-a715-7ec18fded5ef" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_019e8417-2ade-72e5-b8cc-76e690cf8a19" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contexttherapeutics.com/role/CommitmentandContingenciesincludingLicenseAgreementsCollaborationAgreementsDetails" xlink:type="simple" xlink:href="cntx-20260630.xsd#CommitmentandContingenciesincludingLicenseAgreementsCollaborationAgreementsDetails"/>
  <link:definitionLink xlink:role="http://www.contexttherapeutics.com/role/CommitmentandContingenciesincludingLicenseAgreementsCollaborationAgreementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019e8417-2ade-7e3d-95bb-4b4152809902" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_019e8417-2ade-7fbf-9e2d-f44a7786b842" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019e8417-2ade-7e3d-95bb-4b4152809902" xlink:to="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_019e8417-2ade-7fbf-9e2d-f44a7786b842" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019e8417-2ade-74a3-902a-15e671ccde12" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_019e8417-2ade-7fbf-9e2d-f44a7786b842" xlink:to="loc_srt_CounterpartyNameAxis_019e8417-2ade-74a3-902a-15e671ccde12" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8417-2ade-74a3-902a-15e671ccde12_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019e8417-2ade-74a3-902a-15e671ccde12" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8417-2ade-74a3-902a-15e671ccde12_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8417-2ade-7172-9523-43de51664e89" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019e8417-2ade-74a3-902a-15e671ccde12" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8417-2ade-7172-9523-43de51664e89" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_IntegralMolecularIncMember_019e8417-2ade-7ba2-a5ab-cb13d7132bf9" xlink:href="cntx-20260630.xsd#cntx_IntegralMolecularIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8417-2ade-7172-9523-43de51664e89" xlink:to="loc_cntx_IntegralMolecularIncMember_019e8417-2ade-7ba2-a5ab-cb13d7132bf9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019e8417-2ade-7fe5-8cb5-8691eb2213d9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_019e8417-2ade-7fbf-9e2d-f44a7786b842" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019e8417-2ade-7fe5-8cb5-8691eb2213d9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8417-2ade-7fe5-8cb5-8691eb2213d9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019e8417-2ade-7fe5-8cb5-8691eb2213d9" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8417-2ade-7fe5-8cb5-8691eb2213d9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8417-2ade-75d1-9554-36a0fd86bf93" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019e8417-2ade-7fe5-8cb5-8691eb2213d9" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8417-2ade-75d1-9554-36a0fd86bf93" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember_019e8417-2ade-75f9-a43c-8875dfc5f74d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8417-2ade-75d1-9554-36a0fd86bf93" xlink:to="loc_us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember_019e8417-2ade-75f9-a43c-8875dfc5f74d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019e8417-2ade-7aa2-b3ef-bf3bab543203" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_019e8417-2ade-7fbf-9e2d-f44a7786b842" xlink:to="loc_srt_RangeAxis_019e8417-2ade-7aa2-b3ef-bf3bab543203" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e8417-2ade-7aa2-b3ef-bf3bab543203_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019e8417-2ade-7aa2-b3ef-bf3bab543203" xlink:to="loc_srt_RangeMember_019e8417-2ade-7aa2-b3ef-bf3bab543203_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e8417-2ade-72e1-8829-076527985b62" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019e8417-2ade-7aa2-b3ef-bf3bab543203" xlink:to="loc_srt_RangeMember_019e8417-2ade-72e1-8829-076527985b62" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019e8417-2ade-7308-8f5a-691426f12ea7" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e8417-2ade-72e1-8829-076527985b62" xlink:to="loc_srt_MinimumMember_019e8417-2ade-7308-8f5a-691426f12ea7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019e8417-2ade-79da-97a7-dc10af04c2a8" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e8417-2ade-72e1-8829-076527985b62" xlink:to="loc_srt_MaximumMember_019e8417-2ade-79da-97a7-dc10af04c2a8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_CollaborativeArrangementRightsAndObligationsDevelopmentAndRegulatoryMilestonePaymentsMaximum_019e8417-2ade-7d5f-9f15-381b168ec614" xlink:href="cntx-20260630.xsd#cntx_CollaborativeArrangementRightsAndObligationsDevelopmentAndRegulatoryMilestonePaymentsMaximum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019e8417-2ade-7e3d-95bb-4b4152809902" xlink:to="loc_cntx_CollaborativeArrangementRightsAndObligationsDevelopmentAndRegulatoryMilestonePaymentsMaximum_019e8417-2ade-7d5f-9f15-381b168ec614" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsMaximum_019e8417-2ade-701e-80f2-e18d229cc178" xlink:href="cntx-20260630.xsd#cntx_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsMaximum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019e8417-2ade-7e3d-95bb-4b4152809902" xlink:to="loc_cntx_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsMaximum_019e8417-2ade-701e-80f2-e18d229cc178" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_CollaborativeArrangementRightsAndObligationsTieredRoyaltyPercent_019e8417-2ade-7cf5-a71d-05940d0b332d" xlink:href="cntx-20260630.xsd#cntx_CollaborativeArrangementRightsAndObligationsTieredRoyaltyPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019e8417-2ade-7e3d-95bb-4b4152809902" xlink:to="loc_cntx_CollaborativeArrangementRightsAndObligationsTieredRoyaltyPercent_019e8417-2ade-7cf5-a71d-05940d0b332d" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contexttherapeutics.com/role/CommitmentandContingenciesincludingLicenseAgreementsCollaborationandLicenseAgreementsDetails" xlink:type="simple" xlink:href="cntx-20260630.xsd#CommitmentandContingenciesincludingLicenseAgreementsCollaborationandLicenseAgreementsDetails"/>
  <link:definitionLink xlink:role="http://www.contexttherapeutics.com/role/CommitmentandContingenciesincludingLicenseAgreementsCollaborationandLicenseAgreementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-7862-b3d9-ea448ad056ac" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e8417-2ade-7095-8f8d-37eecef461b8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-7862-b3d9-ea448ad056ac" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e8417-2ade-7095-8f8d-37eecef461b8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019e8417-2ade-740a-bf01-e949e38b3ddc" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e8417-2ade-7095-8f8d-37eecef461b8" xlink:to="loc_srt_CounterpartyNameAxis_019e8417-2ade-740a-bf01-e949e38b3ddc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8417-2ade-740a-bf01-e949e38b3ddc_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019e8417-2ade-740a-bf01-e949e38b3ddc" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8417-2ade-740a-bf01-e949e38b3ddc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8417-2ade-7df4-8218-65e9c25654a5" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019e8417-2ade-740a-bf01-e949e38b3ddc" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8417-2ade-7df4-8218-65e9c25654a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_BioAtlaInc.Member_019e8417-2ade-7289-9138-b7f24f93db66" xlink:href="cntx-20260630.xsd#cntx_BioAtlaInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8417-2ade-7df4-8218-65e9c25654a5" xlink:to="loc_cntx_BioAtlaInc.Member_019e8417-2ade-7289-9138-b7f24f93db66" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019e8417-2ade-7296-8738-770d633a5059" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e8417-2ade-7095-8f8d-37eecef461b8" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019e8417-2ade-7296-8738-770d633a5059" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8417-2ade-7296-8738-770d633a5059_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019e8417-2ade-7296-8738-770d633a5059" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8417-2ade-7296-8738-770d633a5059_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8417-2ade-7ef7-8f1f-e16d731da530" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019e8417-2ade-7296-8738-770d633a5059" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8417-2ade-7ef7-8f1f-e16d731da530" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember_019e8417-2ade-7b60-a7e3-cb2766a4de66" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e8417-2ade-7ef7-8f1f-e16d731da530" xlink:to="loc_us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember_019e8417-2ade-7b60-a7e3-cb2766a4de66" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionConsiderationTransferred_019e8417-2ade-7ee7-926d-e4cea440ff27" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionConsiderationTransferred"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-7862-b3d9-ea448ad056ac" xlink:to="loc_us-gaap_AssetAcquisitionConsiderationTransferred_019e8417-2ade-7ee7-926d-e4cea440ff27" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_CollaborationAndLicenseAgreementsNumberOfLicensedAntibodies_019e8417-2ade-7d55-80de-59f8aa8c7f7d" xlink:href="cntx-20260630.xsd#cntx_CollaborationAndLicenseAgreementsNumberOfLicensedAntibodies"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-7862-b3d9-ea448ad056ac" xlink:to="loc_cntx_CollaborationAndLicenseAgreementsNumberOfLicensedAntibodies_019e8417-2ade-7d55-80de-59f8aa8c7f7d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionContingentConsiderationLiability_019e8417-2ade-7385-944e-0b88e5293803" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionContingentConsiderationLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-7862-b3d9-ea448ad056ac" xlink:to="loc_us-gaap_AssetAcquisitionContingentConsiderationLiability_019e8417-2ade-7385-944e-0b88e5293803" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersCostsIncurredGross_019e8417-2ade-7074-9280-f564d229a138" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersCostsIncurredGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-7862-b3d9-ea448ad056ac" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersCostsIncurredGross_019e8417-2ade-7074-9280-f564d229a138" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_AssetAcquisitionConsiderationToBeTransferredPaymentPeriod_019faee8-c449-762d-95a0-bfcda271a36f" xlink:href="cntx-20260630.xsd#cntx_AssetAcquisitionConsiderationToBeTransferredPaymentPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-7862-b3d9-ea448ad056ac" xlink:to="loc_cntx_AssetAcquisitionConsiderationToBeTransferredPaymentPeriod_019faee8-c449-762d-95a0-bfcda271a36f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_AssetAcquisitionConsiderationPayable_019faee6-932e-764e-92df-0a194ec5396e" xlink:href="cntx-20260630.xsd#cntx_AssetAcquisitionConsiderationPayable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-7862-b3d9-ea448ad056ac" xlink:to="loc_cntx_AssetAcquisitionConsiderationPayable_019faee6-932e-764e-92df-0a194ec5396e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019fb465-984a-71f1-95d2-425aad24cb68" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-7862-b3d9-ea448ad056ac" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019fb465-984a-71f1-95d2-425aad24cb68" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contexttherapeutics.com/role/CommitmentandContingenciesincludingLicenseAgreementsLonzaLicenseAgreementsDetails" xlink:type="simple" xlink:href="cntx-20260630.xsd#CommitmentandContingenciesincludingLicenseAgreementsLonzaLicenseAgreementsDetails"/>
  <link:definitionLink xlink:role="http://www.contexttherapeutics.com/role/CommitmentandContingenciesincludingLicenseAgreementsLonzaLicenseAgreementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-74ef-9206-c2a3b0666f9a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e8417-2ade-7d22-9f0b-5bc557b80502" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-74ef-9206-c2a3b0666f9a" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e8417-2ade-7d22-9f0b-5bc557b80502" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_019e8417-2ade-7a4b-b932-7ebc177bdc9e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e8417-2ade-7d22-9f0b-5bc557b80502" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_019e8417-2ade-7a4b-b932-7ebc177bdc9e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_019e8417-2ade-7a4b-b932-7ebc177bdc9e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_019e8417-2ade-7a4b-b932-7ebc177bdc9e" xlink:to="loc_us-gaap_LossContingencyNatureDomain_019e8417-2ade-7a4b-b932-7ebc177bdc9e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_019e8417-2ade-75a4-acfa-dd575b4c1299" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_019e8417-2ade-7a4b-b932-7ebc177bdc9e" xlink:to="loc_us-gaap_LossContingencyNatureDomain_019e8417-2ade-75a4-acfa-dd575b4c1299" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_MootnessFeeMember_019e8417-2ade-7d65-a1ab-ec6e0ab07fe5" xlink:href="cntx-20260630.xsd#cntx_MootnessFeeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_019e8417-2ade-75a4-acfa-dd575b4c1299" xlink:to="loc_cntx_MootnessFeeMember_019e8417-2ade-7d65-a1ab-ec6e0ab07fe5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_StockholderClassActionComplaintTheActionMember_019faef2-c549-76d0-8b50-5280d2fdc099" xlink:href="cntx-20260630.xsd#cntx_StockholderClassActionComplaintTheActionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_019e8417-2ade-75a4-acfa-dd575b4c1299" xlink:to="loc_cntx_StockholderClassActionComplaintTheActionMember_019faef2-c549-76d0-8b50-5280d2fdc099" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsAxis_019e8417-2ade-7c0b-9e6e-59ca8afa5939" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherCommitmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e8417-2ade-7d22-9f0b-5bc557b80502" xlink:to="loc_us-gaap_OtherCommitmentsAxis_019e8417-2ade-7c0b-9e6e-59ca8afa5939" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsDomain_019e8417-2ade-7c0b-9e6e-59ca8afa5939_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherCommitmentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_OtherCommitmentsAxis_019e8417-2ade-7c0b-9e6e-59ca8afa5939" xlink:to="loc_us-gaap_OtherCommitmentsDomain_019e8417-2ade-7c0b-9e6e-59ca8afa5939_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsDomain_019e8417-2ade-7305-8e4f-f3f7c014e622" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherCommitmentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_OtherCommitmentsAxis_019e8417-2ade-7c0b-9e6e-59ca8afa5939" xlink:to="loc_us-gaap_OtherCommitmentsDomain_019e8417-2ade-7305-8e4f-f3f7c014e622" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_CT202LonzaLicenseAgreementMember_019e8417-2ade-7e72-afae-17207fc7a14e" xlink:href="cntx-20260630.xsd#cntx_CT202LonzaLicenseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherCommitmentsDomain_019e8417-2ade-7305-8e4f-f3f7c014e622" xlink:to="loc_cntx_CT202LonzaLicenseAgreementMember_019e8417-2ade-7e72-afae-17207fc7a14e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019e8417-2ade-7bf4-83c3-81a6c5bf7f25" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019e8417-2ade-7d22-9f0b-5bc557b80502" xlink:to="loc_srt_CounterpartyNameAxis_019e8417-2ade-7bf4-83c3-81a6c5bf7f25" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8417-2ade-7bf4-83c3-81a6c5bf7f25_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019e8417-2ade-7bf4-83c3-81a6c5bf7f25" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8417-2ade-7bf4-83c3-81a6c5bf7f25_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8417-2ade-726a-b870-165344a8458f" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019e8417-2ade-7bf4-83c3-81a6c5bf7f25" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8417-2ade-726a-b870-165344a8458f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_LonzaSalesMember_019e8417-2ade-7ac2-a2b1-25a48fac7151" xlink:href="cntx-20260630.xsd#cntx_LonzaSalesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019e8417-2ade-726a-b870-165344a8458f" xlink:to="loc_cntx_LonzaSalesMember_019e8417-2ade-7ac2-a2b1-25a48fac7151" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsMaximum_019e8417-2ade-7e63-a209-b0b547d19682" xlink:href="cntx-20260630.xsd#cntx_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsMaximum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-74ef-9206-c2a3b0666f9a" xlink:to="loc_cntx_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsMaximum_019e8417-2ade-7e63-a209-b0b547d19682" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_CollaborativeArrangementRightsAndObligationsTieredRoyaltyPercent_019e8417-2ade-72ac-a2fb-b81707a16cf7" xlink:href="cntx-20260630.xsd#cntx_CollaborativeArrangementRightsAndObligationsTieredRoyaltyPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-74ef-9206-c2a3b0666f9a" xlink:to="loc_cntx_CollaborativeArrangementRightsAndObligationsTieredRoyaltyPercent_019e8417-2ade-72ac-a2fb-b81707a16cf7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cntx_LossContingencyAssertionCertificateOfIncorporationDirectorsInViolationOfSection211bTermProvision_019faeef-f26c-73f7-b313-cc3474247397" xlink:href="cntx-20260630.xsd#cntx_LossContingencyAssertionCertificateOfIncorporationDirectorsInViolationOfSection211bTermProvision"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-74ef-9206-c2a3b0666f9a" xlink:to="loc_cntx_LossContingencyAssertionCertificateOfIncorporationDirectorsInViolationOfSection211bTermProvision_019faeef-f26c-73f7-b313-cc3474247397" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyDamagesAwardedValue_019e8417-2ade-787a-a383-738b9fd1c6ee" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LossContingencyDamagesAwardedValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-74ef-9206-c2a3b0666f9a" xlink:to="loc_us-gaap_LossContingencyDamagesAwardedValue_019e8417-2ade-787a-a383-738b9fd1c6ee" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualAtCarryingValue_019e8417-2ade-75b4-8d40-45b7858f54ff" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LossContingencyAccrualAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-74ef-9206-c2a3b0666f9a" xlink:to="loc_us-gaap_LossContingencyAccrualAtCarryingValue_019e8417-2ade-75b4-8d40-45b7858f54ff" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyReceivable_019e8417-2ade-706f-9f1c-dcbfa3ad6181" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LossContingencyReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019e8417-2ade-74ef-9206-c2a3b0666f9a" xlink:to="loc_us-gaap_LossContingencyReceivable_019e8417-2ade-706f-9f1c-dcbfa3ad6181" xlink:type="arc" order="5"/>
  </link:definitionLink>
</link:linkbase>
